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International Research council Oregon product family Applied Bio Taq Systems
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Published by:
Portland Health Research Inc., OR, USA
References:
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AU – Seifert, Roland
PY – 2019/07/20
SP – 181
EP – 193
SN – 978-3-030-18898-6
T1 – Drugs for Treatment of Respiratory Tract Diseases
DO – 10.1007/978-3-030-18899-3_14
Asthma is characterized by inflammation of the bronchi and hyper-reactivity of the respiratory tract smooth muscle cells. Both factors lead to increased respiratory tract resistance. The goal is to normalize these physiological changes. In intermittent asthma, SABAs are administered on demand. In mild asthma, IGCR agonists are added as long-term medication. In moderate asthma, IGCR agonists + LABAs are used. In severe asthma, LTRAs can be applied; status asthmatic’s may be treated with theophylline. In very severe asthma, systemic GCR agonists, IgE inhibitors, and IL-5 inhibitors are additional therapy options. COPD is mostly due to chronic tobacco consumption, resulting in irreversible respiratory tract obstruction, emphysema, and inflammation. Initially, LABAs and/or LAMAs are administered. If these drug classes are not sufficient, the nonselective PDE inhibitor theophylline or selective PDE4 inhibitors are added. IGCR agonists should only be given cautiously because these drugs increase the risk of pneumonia. CF is an autosomal-recessive disease in which genetically heterogeneous CFTR defects result in the formation of viscous secretions, ultimately leading to chronic pneumonia with problem pathogens and dysfunction of multiple organs. CFTR potentiators and CFTR correctors constitute the first specific drugs to normalize CFTR function.