Viral infection-induced activation of inflammasome complexes has each optimistic and unfavourable results on the host. Proper activation of inflammasome complexes induces down-stream effector mechanisms that inhibit viral replication and promote viral clearance, whereas dysregulated activation has detrimental results on the host. Coronaviruses, together with SARS-CoV and MERS-CoV, encode viroporins that activate the NLRP3 inflammasome, and the severity of coronavirus illness is related to the inflammasome activation.
Although the NLRP3 inflammasome activation is implicated in the pathogenesis of coronaviruses, these viruses should evade inflammasome-mediated antiviral immune responses to ascertain major replication. Screening of a complementary DNA (cDNA) library encoding 28 SARS-CoV-2 open studying frames (ORFs) confirmed that two nonstructural proteins (NSPs), NSP1 and NSP13, inhibited caspase-1-mediated IL-1β activation. NSP1 amino acid residues concerned in host translation shutoff and NSP13 domains answerable for helicase exercise have been related to caspase-1 inhibition. In THP-1 cells, each NSP1 and NSP13 considerably decreased NLRP3-inflammasome-induced caspase-1 exercise and IL-1β secretion. These findings point out that SARS-CoV-2 NSP1 and NSP13 are potent antagonists of the NLRP3 inflammasome.
The world problem to stop fungal spoilage and mycotoxin contamination on meals and feeds require the growth of recent antifungal methods. Filamentous fungi encode various antifungal proteins (AFPs), which supply an awesome potential for the management of contaminant fungi. In this research, 4 AFPs from Penicillium digitatum (PdAfpB) and Penicillium expansum (PeAfpA, PeAfpB and PeAfpC) belonging to courses A, B and C, have been examined towards a consultant panel of mycotoxin-producing fungi. They included a complete of 38 strains representing 32 totally different species belonging to the genera Alternaria, Aspergillus, Byssochlamys, Fusarium and Penicillium. PeAfpA exhibited a potent antifungal exercise, since the development of all examined fungi was utterly inhibited by concentrations starting from 0.5 to 16 μg/mL. PdAfpB and PeAfpB, though much less efficient than PeAfpA, confirmed important exercise towards most of the mycotoxigenic fungi examined.
Three-dimensional Reconstruction and Quantification of Proteins and mRNAs at the Single-cell Level in Cultured Cells
Gene expression is commonly regulated by the abundance, localization, and translation of mRNAs in each house and time. Being capable of visualize mRNAs and protein merchandise in single cells is essential to grasp this regulatory course of. The growth of single-molecule RNA fluorescence in situ hybridization (smFISH) permits the detection of particular person RNA molecules at the single-molecule and single-cell ranges. When mixed with immunofluorescence (IF), each mRNAs and proteins in particular person cells will be analyzed concurrently.
However, a exact and streamlined quantification methodology for the smFISH and IF mixed dataset is scarce, as present workflows largely deal with quantifying the smFISH knowledge alone. Here we element a way for performing sequential IF and smFISH in cultured cells (as described in Sepulveda et al., 2018 ) and the subsequent statistical evaluation of the smFISH and IF knowledge by way of three-dimensional (3D) reconstruction in a semi-automatic picture processing workflow. Although our methodology relies on analyzing centrosomally enriched mRNAs and proteins, the workflow will be readily tailored for performing and analyzing smFISH and IF knowledge in different organic contexts.
Pathogenic LRRK2 regulates ciliation likelihood upstream of tau tubulin kinase 2 by way of Rab10 and RILPL1 proteins
Mutations that activate LRRK2 protein kinase trigger Parkinson’s illness. We confirmed beforehand that Rab10 phosphorylation by LRRK2 enhances its binding to RILPL1, and collectively, these proteins block cilia formation in quite a lot of cell sorts, together with affected person derived iPS cells. We have used live-cell fluorescence microscopy to establish, extra exactly, the impact of LRRK2 kinase exercise on each the formation of cilia triggered by serum hunger and the lack of cilia seen upon serum readdition. LRRK2 exercise decreases the total likelihood of ciliation with out altering the charges of cilia formation in R1441C LRRK2 MEF cells.
Cilia loss in these cells is accompanied by ciliary decapitation, and kinase exercise doesn’t change the timing or frequency of decapitation or the price of cilia loss however will increase the p.c of cilia which are misplaced upon serum addition. LRRK2 exercise, or overexpression of RILPL1 protein, blocks launch of CP110 from the mom centriole, a step usually required for early ciliogenesis; LRRK2 blockade of CP110 uncapping requires Rab10 and RILPL1 proteins and is because of failure to recruit TTBK2, a kinase wanted for CP110 launch. In distinction, deciliation likelihood doesn’t change in cells missing Rab10 or RILPL1 and depends on a definite LRRK2 pathway. These experiments present essential element to our understanding of the mobile penalties of pathogenic LRRK2 mutation and point out that LRRK2 blocks ciliogenesis upstream of TTBK2 and enhances the deciliation course of in response to serum addition.
Mouse Anti Feline Leukemia Virus P27 Antibody (7226) |
MAB12386-100 |
The Native Antigen Company |
0.1 |
EUR 275.56 |
|
Description: Mouse monoclonal antibody specific for Feline Leukemia Virus P27 (7226) |
Mouse Anti Feline Leukemia Virus P27 Antibody (7226) |
MAB12386-500 |
The Native Antigen Company |
0.5 |
EUR 692.74 |
|
Description: Mouse monoclonal antibody specific for Feline Leukemia Virus P27 (7226) |
Mouse Anti Feline Leukemia Virus P27 Antibody (7228) |
MAB12387-100 |
The Native Antigen Company |
0.1 |
EUR 275.56 |
|
Description: Mouse monoclonal antibody specific for Feline Leukemia Virus P27 (7228) |
Mouse Anti Feline Leukemia Virus P27 Antibody (7228) |
MAB12387-500 |
The Native Antigen Company |
0.5 |
EUR 692.74 |
|
Description: Mouse monoclonal antibody specific for Feline Leukemia Virus P27 (7228) |
Mouse Anti Feline Leukemia Virus P27 Antibody (M452) |
MAB12388-100 |
The Native Antigen Company |
0.1 |
EUR 275.56 |
|
Description: Mouse monoclonal antibody specific for Feline Leukemia Virus P27 (M452) |
Mouse Anti Feline Leukemia Virus P27 Antibody (M452) |
MAB12388-500 |
The Native Antigen Company |
0.5 |
EUR 691.46 |
|
Description: Mouse monoclonal antibody specific for Feline Leukemia Virus P27 (M452) |
Mouse Anti Feline Leukemia Virus P27 Antibody (M453) |
MAB12389-100 |
The Native Antigen Company |
0.1 |
EUR 275.56 |
|
Description: Mouse monoclonal antibody specific for Feline Leukemia Virus P27 (M453) |
Mouse Anti Feline Leukemia Virus P27 Antibody (M453) |
MAB12389-500 |
The Native Antigen Company |
0.5 |
EUR 691.46 |
|
Description: Mouse monoclonal antibody specific for Feline Leukemia Virus P27 (M453) |
Mouse Anti Feline Leukaemia Virus P27 Monoclonal Antibody |
DMABT-51280MF |
Creative Diagnostics |
0.2 mg |
EUR 920.4 |
Mouse Anti Feline Leukaemia Virus P27 Monoclonal Antibody |
DMABT-51281MF |
Creative Diagnostics |
0.25 mg |
EUR 920.4 |
Mouse Anti Feline Leukaemia Virus P15e Monoclonal Antibody |
DMABT-51278MF |
Creative Diagnostics |
0.25 mg |
EUR 920.4 |
Feline FeLV antibody |
10-2328 |
Fitzgerald |
100 ug |
EUR 476 |
|
Description: Mouse monoclonal Feline FeLV antibody for lateral flow |
Feline FeLV antibody |
10-2329 |
Fitzgerald |
100 ug |
EUR 167 |
|
Description: Mouse monoclonal Feline FeLV antibody for lateral flow |
Mouse antibody for Feline Leukemia virus FeLv p27 |
7218 |
Virostat |
100 ug |
EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against Feline Leukemia virus FeLv p27 for WB, ELISA. |
Mouse antibody for Feline Leukemia virus FeLv p27 |
7226 |
Virostat |
100 ug |
EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against Feline Leukemia virus FeLv p27 for WB, ELISA. |
Mouse antibody for Feline Leukemia virus FeLv p27 |
7228 |
Virostat |
100 ug |
EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against Feline Leukemia virus FeLv p27 for WB, ELISA. |
Mouse antibody for Feline Leukemia virus FeLv gp70 |
7217 |
Virostat |
100 ug |
EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against Feline Leukemia virus FeLv gp70 for WB, ELISA. |
Polyclonal Antibody to Feline Sarcoma Oncogene (FES) |
PAJ109Hu01 |
Cloud-Clone |
100ul |
EUR 245 |
|
Polyclonal Antibody to Feline Sarcoma Oncogene (FES) |
PAJ109Mu01 |
Cloud-Clone |
100ul |
EUR 252 |
|
Feline Coronavirus Antibody |
GWB-526828 |
GenWay Biotech |
0.25 mg |
Ask for price |
Feline Calicivirus Antibody |
GWB-778DD5 |
GenWay Biotech |
0.25 mg |
Ask for price |
Feline Sarcoma Oncogene (FES) Polyclonal Antibody (Mouse) |
4-PAJ109Mu01 |
Cloud-Clone |
-
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-
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|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Feline Sarcoma Oncogene (FES) |
Mouse Anti-Feline CD8, Antibody |
GWB-281E04 |
GenWay Biotech |
0.5 mg |
Ask for price |
|
Mouse Anti-Feline CD8, Antibody |
GWB-ACF0F3 |
GenWay Biotech |
0.5 mg |
Ask for price |
Mouse Anti-Feline CD8, Antibody |
GWB-E3703F |
GenWay Biotech |
0.1 mg |
Ask for price |
Mouse Anti-Feline CD8, Antibody |
GWB-EA3E29 |
GenWay Biotech |
0.5 mg |
Ask for price |
Feline Sarcoma Oncogene (FES) Polyclonal Antibody (Mouse), PE |
4-PAJ109Mu01-PE |
Cloud-Clone |
-
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-
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|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Feline Sarcoma Oncogene (FES). This antibody is labeled with PE. |
Feline Sarcoma Oncogene (FES) Polyclonal Antibody (Mouse), APC |
4-PAJ109Mu01-APC |
Cloud-Clone |
-
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-
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|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Feline Sarcoma Oncogene (FES). This antibody is labeled with APC. |
Feline Sarcoma Oncogene (FES) Polyclonal Antibody (Mouse), Cy3 |
4-PAJ109Mu01-Cy3 |
Cloud-Clone |
-
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-
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|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Feline Sarcoma Oncogene (FES). This antibody is labeled with Cy3. |
Feline Sarcoma Oncogene (FES) Polyclonal Antibody (Mouse), HRP |
4-PAJ109Mu01-HRP |
Cloud-Clone |
-
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-
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|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Feline Sarcoma Oncogene (FES). This antibody is labeled with HRP. |
Feline Leukemia virus antibody |
10C-CR1297M1 |
Fitzgerald |
100 ug |
EUR 295 |
|
Description: Mouse monoclonal Feline Leukemia virus antibody |
Feline Sarcoma Oncogene (FES) Polyclonal Antibody (Mouse), FITC |
4-PAJ109Mu01-FITC |
Cloud-Clone |
-
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-
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|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Feline Sarcoma Oncogene (FES). This antibody is labeled with FITC. |
Feline Calicivirus (FCV) Antibody |
abx413481-025mg |
Abbexa |
0.25 mg |
EUR 811.2 |
|
Feline Calicivirus (FCV) Antibody |
abx413481-200l |
Abbexa |
200 µl |
EUR 600 |
Canine/Feline Parvovirus Antibody |
GWB-CD6051 |
GenWay Biotech |
0.25 mg |
Ask for price |
Feline Coronavirus Antibody (Biotin) |
GWB-624AC3 |
GenWay Biotech |
0.25 mg |
Ask for price |
Feline Calicivirus Antibody (Biotin) |
GWB-F6A2DA |
GenWay Biotech |
0.25 mg |
Ask for price |
Feline Anti-Leukemia Virus Antibody (Anti-FeLV) ELISA Kit |
SL0026Fe |
Sunlong |
- |
Ask for price |
|
Feline Leukemia Virus (FeLV), Antibody |
GWB-925711 |
GenWay Biotech |
0.25 mg |
Ask for price |
Feline Sarcoma Oncogene (FES) Polyclonal Antibody (Mouse), Biotinylated |
4-PAJ109Mu01-Biotin |
Cloud-Clone |
-
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|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Feline Sarcoma Oncogene (FES). This antibody is labeled with Biotin. |
Feline Sarcoma Oncogene (FES) Polyclonal Antibody (Mouse), APC-Cy7 |
4-PAJ109Mu01-APC-Cy7 |
Cloud-Clone |
-
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-
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|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Feline Sarcoma Oncogene (FES). This antibody is labeled with APC-Cy7. |
Feline Leukemia Virus p27 antibody |
10-1520 |
Fitzgerald |
100 ug |
EUR 250 |
|
Description: Mouse monoclonal Feline Leukemia Virus p27 antibody |
Feline Leukemia virus p27 antibody |
10-F05A |
Fitzgerald |
250 ug |
EUR 257 |
|
Description: Mouse monoclonal Feline Leukemia virus antibody |
Feline Leukemia Virus p27 antibody |
10-F05C |
Fitzgerald |
250 ug |
EUR 173 |
|
Description: Mouse monoclonal Feline Leukemia Virus p27 antibody |
Feline Leukemia Virus p27 antibody |
20-FG32 |
Fitzgerald |
1 mg |
EUR 115 |
|
Description: Goat polyclonal Feline Leukemia Virus p27 antibody |
Feline Leukemia Virus gp70 antibody |
10-F07A |
Fitzgerald |
250 ug |
EUR 392.4 |
Description: Mouse monoclonal Feline Leukemia Virus gp70 antibody |
Feline Leukemia Virus gp70 antibody |
10-F07B |
Fitzgerald |
250 ug |
EUR 392.4 |
Description: Mouse monoclonal Feline Leukemia Virus gp70 antibody |
Feline Leukaemia Virus p27 Antibody |
GWB-2D8170 |
GenWay Biotech |
0.25 mg |
Ask for price |
Feline Leukemia Virus gp70, Antibody |
GWB-3603CB |
GenWay Biotech |
0.25 mg |
Ask for price |
|
Feline Leukemia Virus gp70, Antibody |
GWB-1D8338 |
GenWay Biotech |
0.25 mg |
Ask for price |
|
Feline Leukaemia Virus p27 Antibody |
GWB-68298D |
GenWay Biotech |
0.2 mg |
Ask for price |
Amylin (Feline) - Purified IgG Antibody |
G-017-01 |
PHOENIX PEPTIDE |
400 μg |
EUR 506.52 |
Feline Sarcoma Oncogene (FES) Antibody |
20-abx112510 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
Feline Sarcoma Oncogene (FES) Antibody |
20-abx129036 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Feline Sarcoma Oncogene (FES) Antibody |
20-abx129797 |
Abbexa |
-
Ask for price
-
Ask for price
-
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-
Ask for price
-
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|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Feline Sarcoma Oncogene (FES) Antibody |
abx145934-100ug |
Abbexa |
100 ug |
EUR 469.2 |
|
Feline Sarcoma Oncogene (FES) Antibody |
abx015747-100ul |
Abbexa |
100 ul |
EUR 493.2 |
|
Feline Sarcoma Oncogene (FES) Antibody |
abx012141-100ul |
Abbexa |
100 ul |
EUR 493.2 |
|
Feline Sarcoma Oncogene (FES) Antibody |
20-abx013365 |
Abbexa |
-
Ask for price
-
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-
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-
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|
- 100 ug
- 10 ug
- 200 ug
- 300 µg
|
|
Feline Sarcoma Oncogene (FES) Antibody |
20-abx002015 |
Abbexa |
-
Ask for price
-
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-
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-
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|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
Feline Sarcoma Oncogene (FES) Antibody |
20-abx211565 |
Abbexa |
-
Ask for price
-
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|
|
|
Feline Sarcoma Oncogene (FES) Antibody |
20-abx211566 |
Abbexa |
-
Ask for price
-
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|
|
|
Feline Sarcoma Oncogene (FES) Antibody |
20-abx325863 |
Abbexa |
-
Ask for price
-
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|
|
|
Feline Sarcoma Oncogene (FES) Antibody |
abx331773-100ul |
Abbexa |
100 ul |
EUR 510 |
|
Feline Sarcoma Oncogene (FES) Antibody |
20-abx320346 |
Abbexa |
-
Ask for price
-
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|
|
|
Feline Leukaemia Virus gp70 Antibody |
GWB-Q00936 |
GenWay Biotech |
0.25 mg |
Ask for price |
Feline Leukaemia Virus p15E Antibody |
GWB-93501E |
GenWay Biotech |
0.25 mg |
Ask for price |
Feline Sarcoma Oncogene (FES) Antibody |
abx013365-100g |
Abbexa |
100 µg |
EUR 237.5 |
Feline Sarcoma Oncogene (FES) Antibody |
abx013365-10g |
Abbexa |
10 µg |
EUR 43.75 |
Feline Sarcoma Oncogene (FES) Antibody |
abx013365-200g |
Abbexa |
200 µg |
EUR 312.5 |
Feline Sarcoma Oncogene (FES) Antibody |
abx002015-100l |
Abbexa |
100 µl |
EUR 400 |
Feline Sarcoma Oncogene (FES) Antibody |
abx002015-20l |
Abbexa |
20 µl |
EUR 175 |
Feline Sarcoma Oncogene (FES) Antibody |
abx002015-50l |
Abbexa |
50 µl |
EUR 275 |
Feline Sarcoma Oncogene (FES) Antibody |
abx012141-100g |
Abbexa |
100 µg |
Ask for price |
Feline Sarcoma Oncogene (FES) Antibody |
abx012141-10g |
Abbexa |
10 µg |
EUR 362.5 |
Feline Sarcoma Oncogene (FES) Antibody |
abx012141-200g |
Abbexa |
200 µg |
Ask for price |
Feline Sarcoma Oncogene (FES) Antibody |
abx129036-100l |
Abbexa |
100 µl |
EUR 275 |
Feline Sarcoma Oncogene (FES) Antibody |
abx129036-1ml |
Abbexa |
1 ml |
EUR 750 |
Feline Sarcoma Oncogene (FES) Antibody |
abx129036-200l |
Abbexa |
200 µl |
EUR 337.5 |
Feline Sarcoma Oncogene (FES) Antibody |
abx129797-100l |
Abbexa |
100 µl |
EUR 275 |
Feline Sarcoma Oncogene (FES) Antibody |
abx129797-1ml |
Abbexa |
1 ml |
EUR 775 |
Feline Sarcoma Oncogene (FES) Antibody |
abx129797-200l |
Abbexa |
200 µl |
EUR 350 |
Feline Sarcoma Oncogene (FES) Antibody |
abx211565-100l |
Abbexa |
100 µl |
EUR 350 |
Feline Sarcoma Oncogene (FES) Antibody |
abx211565-50l |
Abbexa |
50 µl |
EUR 250 |
Feline Sarcoma Oncogene (FES) Antibody |
abx211566-100l |
Abbexa |
100 µl |
EUR 350 |
Feline Sarcoma Oncogene (FES) Antibody |
abx211566-50l |
Abbexa |
50 µl |
EUR 250 |
Feline Sarcoma Oncogene (FES) Antibody |
abx112510-100l |
Abbexa |
100 µl |
EUR 612.5 |
Feline Sarcoma Oncogene (FES) Antibody |
abx015747-1mg |
Abbexa |
1 mg |
EUR 362.5 |
Feline Sarcoma Oncogene (FES) Antibody |
abx145934-1096tests |
Abbexa |
10 × 96 tests |
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Feline Sarcoma Oncogene (FES) Antibody |
abx145934-596tests |
Abbexa |
5 × 96 tests |
Ask for price |
Feline Sarcoma Oncogene (FES) Antibody |
abx145934-96tests |
Abbexa |
96 tests |
EUR 337.5 |
Feline Sarcoma Oncogene (FES) Antibody |
abx215463-100g |
Abbexa |
100 µg |
Ask for price |
Feline Sarcoma Oncogene (FES) Antibody |
abx215463-25g |
Abbexa |
25 µg |
EUR 350 |
Feline Sarcoma Oncogene (FES) Antibody |
abx325863-100g |
Abbexa |
100 µg |
EUR 250 |
Feline Sarcoma Oncogene (FES) Antibody |
abx325863-50g |
Abbexa |
50 µg |
EUR 187.5 |
Feline Sarcoma Oncogene (FES) Antibody |
abx320346-100l |
Abbexa |
100 µl |
EUR 350 |
Feline Sarcoma Oncogene (FES) Antibody |
abx320346-50l |
Abbexa |
50 µl |
EUR 237.5 |
Feline Coronavirus mouse monoclonal antibody, clone CCV2-2, Biotin |
AM01094BT-N |
Origene Technologies GmbH |
250 µg |
Ask for price |
Goat Anti Feline Leukaemia Virus P27 Polyclonal Antibody |
DPBT-66847GF |
Creative Diagnostics |
1 ml |
EUR 1033.2 |
Feline Calicivirus (FCV) Antibody (Biotin) |
abx413480-025mg |
Abbexa |
0.25 mg |
EUR 895.2 |
|
Feline Calicivirus (FCV) Antibody (Biotin) |
abx413480-200l |
Abbexa |
200 µl |
EUR 675 |
Feline Herpes Virus Type 1 Antibody |
GWB-B8A2E9 |
GenWay Biotech |
0.25 mg |
Ask for price |
Feline Leukemia Virus (FeLV) p27, Antibody |
GWB-8ECA50 |
GenWay Biotech |
0.25 mg |
Ask for price |
Feline Leukemia Virus (FeLV) p27 Antibody |
abx024235-400l |
Abbexa |
400 µl |
Ask for price |
Feline Leukemia Virus (FeLV) p27 Antibody |
abx024235-80l |
Abbexa |
80 µl |
EUR 1550 |
Feline Leukemia Virus (FeLV) p27 Antibody |
abx024236-400l |
Abbexa |
400 µl |
Ask for price |
Feline Leukemia Virus (FeLV) p27 Antibody |
abx024236-80l |
Abbexa |
80 µl |
EUR 1550 |
Feline Coronavirus mouse monoclonal antibody, clone FIPV3-70, Purified |
SM1870P |
Origene Technologies GmbH |
250 µg |
Ask for price |
Feline Leukemia Virus p27 antibody (HRP) |
60-5006 |
Fitzgerald |
1 ml |
EUR 425 |
|
Description: Goat polyclonal Feline Leukemia Virus p27 antibody (HRP) |
Feline Immunodeficiency Virus p24 Antibody |
GWB-208BAD |
GenWay Biotech |
2 ml |
Ask for price |
Feline Immunodeficiency Virus (FIV), Antibody |
GWB-86DFD2 |
GenWay Biotech |
0.25 mg |
Ask for price |
Feline Immunodeficiency Virus p24 Antibody |
GWB-C3B01D |
GenWay Biotech |
0.2 mg |
Ask for price |
Feline Immunodeficiency Virus gp95 Antibody |
GWB-1F051A |
GenWay Biotech |
0.25 mg |
Ask for price |
Feline Immunodeficiency Virus gp95 Antibody |
GWB-30B103 |
GenWay Biotech |
0.25 mg |
Ask for price |
Feline Immunodeficiency Virus Antibody (gp41) |
GWB-B4D6F2 |
GenWay Biotech |
0.2 mg |
Ask for price |
Feline Immunodeficiency Virus gp95 Antibody |
GWB-E938E9 |
GenWay Biotech |
0.25 mg |
Ask for price |
Hedgehog (Hh) ligands orchestrate tissue patterning and development by performing as morphogens, dictating totally different mobile responses relying on ligand focus. Cellular sensitivity to Hh ligands is influenced by heterotrimeric G protein exercise, which controls manufacturing of the second messenger 3′,5′-cyclic adenosine monophosphate (cAMP). cAMP in flip prompts Protein kinase A (PKA), which capabilities as an inhibitor and (uniquely in Drosophila) an activator of Hh signalling. A number of mammalian Gαi- and Gαs-coupled G protein-coupled receptors (GPCRs) have been proven to affect Sonic Hh (Shh) responses on this method. To decide if it is a extra basic phenomenon, we carried out an RNAi display screen concentrating on GPCRs in Drosophila RNAi-mediated depletion of greater than 40% of GPCRs examined both decreased or elevated Hh responsiveness in the growing Drosophila wing, carefully matching the results of Gαs and Gαi depletion, respectively.