Synthesis of Highly Functionalized 2-Pyranone from Silyl Ketene.

Synthesis of Highly Functionalized 2-Pyranone from Silyl Ketene.

We report a extremely functionalized 2-pyranone small molecule ready from tert-butyl diphenyl silyl ketene utilizing an alkoxide catalyst and thermally induced rearrangement. Treatment of the silyl ketene with a substoichiometric quantity of alkoxide led to the formation of a trimer which was remoted and totally characterised; heating this trimer in a 1,4-dioxane resolution induced a thermal rearrangement, yielding the …

Synthesis of Highly Functionalized 2-Pyranone from Silyl Ketene. Read More »