A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines.

Emerging evidence indicates that microtubule-associated proteins (MAPs) are implicated in synaptic function; in particular, mice deficient for MAP6 exhibit striking deficits in plasticity and cognition. How MAP6 connects to plasticity mechanisms is unclear.

Here, we address the possible role of this protein in dendritic spines. We find that in MAP6-deficient cortical and hippocampal neurons, maintenance of mature spines is impaired, and can be restored by expressing a stretch of the MAP6 sequence called Mc modules.

G-5555
MBS3845144-1mg 1mg
EUR 155

G-5555
MBS3845144-50mg 50mg
EUR 1170

G-5555
MBS3845144-5mg 5mg
EUR 280

G-5555
MBS3845144-5x50mg 5x50mg
EUR 5255

G-5555
MBS5753151-10mg 10mg
EUR 215

G-5555
MBS5753151-25mg 25mg
EUR 355

G-5555
MBS5753151-2mg 2mg
EUR 155

G-5555
MBS5753151-50mg 50mg
EUR 590

G-5555
MBS5753151-5mg 5mg
EUR 180

G-9791
MBS5773832-5mg 5(mg
EUR 915

G-9791
MBS5773832-5x5mg 5x5(mg
EUR 3970

G-9791
T24078-10mg 10mg Ask for price
Description: G-9791

G-9791
T24078-1g 1g Ask for price
Description: G-9791

G-9791
T24078-1mg 1mg Ask for price
Description: G-9791

G-9791
T24078-50mg 50mg Ask for price
Description: G-9791

G-9791
T24078-5mg 5mg Ask for price
Description: G-9791

G-5555
T11342L-10mg 10mg Ask for price
Description: G-5555

G-5555
T11342L-1g 1g Ask for price
Description: G-5555

G-5555
T11342L-1mg 1mg Ask for price
Description: G-5555

G-5555
T11342L-50mg 50mg Ask for price
Description: G-5555

G-5555
T11342L-5mg 5mg Ask for price
Description: G-5555

G-749
A8889-1 1 mg
EUR 40
Description: Tyrosine Kinase|FLT3

G-749
A8889-5 5 mg
EUR 112
Description: Tyrosine Kinase|FLT3

G-749
A8889-5.1 10 mM (in 1mL DMSO)
EUR 256.8
Description: Tyrosine Kinase|FLT3

G-749
406593 10.0mg
EUR 250

G-573
406200 250.0mg
EUR 350

G-361
ABC-TC0265 1 vial Ask for price
Description: The cell line is established from a malignant melanoma of a 31 year old male Caucasian.

G-401
ABC-TC0266 1 vial Ask for price
Description: Wilms' tumor (embryonal carcinosarcoma of kidney).

G-402
ABC-TC0267 1 vial Ask for price
Description: Human Caucasian renal leiomyoblastoma. Derived from a tumour of a 9 month old female Caucasian. Highly transformed and grows in soft agar.

G-749
B2213-1 each
EUR 157.2

G-749
B2213-5 each
EUR 418.8

G-749
MBS130907-100mg 100mg
EUR 1065

G-749
MBS130907-500mg 500mg
EUR 2775

G-744
HY-102036 Get quote Ask for price
Description: G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis[1].

G-418
HY-108718 Get quote Ask for price
Description: G-418 (Geneticin) is an aminoglycoside antibiotic with a structure similar to gentamicin. It is toxic to both eukaryotic and prokaryotic cells and works by interfering with protein synthesis[1].

G-479
MBS3840332-2mg 2mg
EUR 290

G-479
MBS3840332-5mg 5mg
EUR 580

G-479
MBS3840332-5x5mg 5x5mg
EUR 2600

G-749
MBS384735-10mg 10mg
EUR 300

G-749
MBS384735-1mLinDMSO 1mL(inDMSO)
EUR 230

G-749
MBS384735-25mg 25mg
EUR 605

G-749
MBS384735-5mg 5mg
EUR 210

G-749
MBS384735-5x25mg 5x25mg
EUR 2705

G-749
MBS3607304-10mg 10mg
EUR 340

G-749
MBS3607304-25mg 25mg
EUR 570

G-749
MBS3607304-2mg 2mg
EUR 240

G-749
MBS3607304-50mg 50mg
EUR 875

G-749
MBS3607304-5mg 5mg
EUR 260

G-744
MBS3844676-10mg 10mg
EUR 1905

G-744
MBS3844676-1mg 1mg
EUR 430

G-744
MBS3844676-5mg 5mg
EUR 1165

G-744
MBS3844676-5x10mg 5x10mg
EUR 8565

G-361
MBS201027-01mg 0.1mg
EUR 215

G-361
MBS201027-02mg 0.2mg
EUR 230

G-361
MBS201027-05mg 0.5mg
EUR 300

G-361
MBS201027-5x05mg 5x0.5mg
EUR 1115

G-749
MBS576599-10mg 10mg
EUR 220

G-749
MBS576599-1mg 1mg
EUR 145

G-749
MBS576599-25mg 25mg
EUR 370

G-749
MBS576599-50mg 50mg
EUR 575

G-749
MBS576599-5mg 5mg
EUR 175

G-744
MBS5769114-5mg 5mg
EUR 915

G-744
MBS5769114-5x5mg 5x5mg
EUR 3970

G-130
MBS5777105-5mg 5(mg
EUR 915

G-130
MBS5777105-5x5mg 5x5(mg
EUR 3970

G-749
T2620-10mg 10mg Ask for price
Description: G-749

G-749
T2620-1g 1g Ask for price
Description: G-749

G-749
T2620-1mg 1mg Ask for price
Description: G-749

G-749
T2620-50mg 50mg Ask for price
Description: G-749

G-749
T2620-5mg 5mg Ask for price
Description: G-749

G-130
T27396-10mg 10mg Ask for price
Description: G-130

G-130
T27396-1g 1g Ask for price
Description: G-130

G-130
T27396-1mg 1mg Ask for price
Description: G-130

G-130
T27396-50mg 50mg Ask for price
Description: G-130

G-130
T27396-5mg 5mg Ask for price
Description: G-130

G-744
T15365-10mg 10mg Ask for price
Description: G-744

G-744
T15365-1g 1g Ask for price
Description: G-744

G-744
T15365-1mg 1mg Ask for price
Description: G-744

G-744
T15365-50mg 50mg Ask for price
Description: G-744

G-744
T15365-5mg 5mg Ask for price
Description: G-744

G-5555 (hydrochloride)
HY-19635A 10mg
EUR 119.05
Description: G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.

G-5555 hydrochloride
MBS5753150-10mg 10mg
EUR 280

G-5555 hydrochloride
MBS5753150-25mg 25mg
EUR 505

G-5555 hydrochloride
MBS5753150-5mg 5mg
EUR 215

G-5555 hydrochloride
MBS5753150-5x25mg 5x25mg
EUR 2125

G-5555 hydrochloride
T63719-10mg 10mg Ask for price
Description: G-5555 hydrochloride

G-5555 hydrochloride
T63719-1g 1g Ask for price
Description: G-5555 hydrochloride

G-5555 hydrochloride
T63719-1mg 1mg Ask for price
Description: G-5555 hydrochloride

G-5555 hydrochloride
T63719-50mg 50mg Ask for price
Description: G-5555 hydrochloride

G-5555 hydrochloride
T63719-5mg 5mg Ask for price
Description: G-5555 hydrochloride

G-418 sulfate
G8160
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 mg
  • 1 g
  • 25 g

G-418 Sulfate
G8161
  • Ask for price
  • Ask for price
  • 100 mg
  • 1 g

Sephadex G-100
abx082118-25g 25 g
EUR 526.8

Sephadex G-100
Se-481C 100 g
EUR 1336
Description: Chromatography Reagents

G-418 (disulfate)
HY-17561 5g
EUR 54.11
Description: G-418 disulfate (Geneticin sulfate), is an aminoglycoside antibiotic, inhibits protein synthesis in eukaryotes and prokaryotes. G-418 disulfate is commonly used as a selective agent for eukaryotic cells[1].

G-418 disulfate
MBS3600328-200mg 200mg
EUR 200

G-418 disulfate
MBS3600328-5x200mg 5x200mg
EUR 580

G-418 disulfate
MBS3845437-500mg 500mg
EUR 135

G-418 disulfate
MBS3845437-5x500mg 5x500mg
EUR 600

G-418 disulfate
T6512-10mg 10mg Ask for price
Description: G-418 disulfate

G-418 disulfate
T6512-1g 1g Ask for price
Description: G-418 disulfate

G-418 disulfate
T6512-1mg 1mg Ask for price
Description: G-418 disulfate

G-418 disulfate
T6512-50mg 50mg Ask for price
Description: G-418 disulfate

G-418 disulfate
T6512-5mg 5mg Ask for price
Description: G-418 disulfate

G-418 SULFATE - 10g
PM-A4215/10 10g
EUR 244.42

1530-G AB Labels
015316 Pack of 250 Label(s)
EUR 49.65
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnen- en buitengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur et extérieur

1534-G AB Labels
015356 Pack of 250 Label(s)
EUR 62.44
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnen- en buitengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur et extérieur

1560-G AB Labels
097106 Pack of 125 Label(s)
EUR 138.01
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnen- en buitengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur et extérieur

1570-G AB Labels
097576 Pack of 25 Label(s)
EUR 138.01
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnen- en buitengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur et extérieur

9714-G AB Labels
097688 Pack of 125 Label(s)
EUR 96.17
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnen- en buitengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur et extérieur

1520-G AB Labels
044016 Pack of 800 Label(s)
EUR 49.65
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnen- en buitengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur et extérieur

1550-G AB Labels
044061 Pack of 150 Label(s)
EUR 92.73
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnen- en buitengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur et extérieur

3400-G AB Labels
034017 Pack of 3600 Label(s)
EUR 40.29
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur

3410-G AB Labels
034117 Pack of 1950 Label(s)
EUR 53.38
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur

3420-G AB Labels
034217 Pack of 800 Label(s)
EUR 39.65
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur

3430-G AB Labels
034317 Pack of 250 Label(s)
EUR 39.65
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur

3440-G AB Labels
034417 Pack of 250 Label(s)
EUR 53.38
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur

3450-G AB Labels
034517 Pack of 150 Label(s)
EUR 77.74
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur

3460-G AB Labels
034617 Pack of 125 Label(s)
EUR 120.82
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur

3470-G AB Labels
034717 Pack of 25 Label(s)
EUR 120.82
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur

9713-G AB Labels
912288 Pack of 250 Label(s)
EUR 70.26
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnen- en buitengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur et extérieur

9712-G AB Labels
912326 Pack of 800 Label(s)
EUR 60.57
Description: Description Dutch: Identieke cijfer- of letterkaarten voor binnen- en buitengebruik; Description French: Chiffres ou lettres identiques par carte - utilisation en intérieur et extérieur

Sephadex G-100 100g - EACH
17006001 EACH
EUR 803.25

G-36
407479 1.0mg
EUR 175

G-15
B5469-10 10 mg
EUR 112
Description: Endocrinology and Hormones|Estrogen/progestogen Receptor

G-36
B5707-10 10 mg
EUR 153.6
Description: Endocrinology and Hormones|Estrogen/progestogen Receptor

G-36
G932038 1mg
EUR 460
Description: 1392487-51-2

G-36
MBS5757275-5mg 5mg
EUR 915

G-36
MBS5757275-5x5mg 5x5mg
EUR 3970

G-15
MBS696269-1mg 1mg
EUR 165

G-15
MBS696269-25mg 25mg
EUR 480

G-15
MBS696269-5x25mg 5x25mg
EUR 2115

G-36
TRC-G932038-5MG 5 mg Ask for price

G-36
TRC-G932038-2.5MG 2.5 mg Ask for price

G-36
TRC-G932038-1MG 1 mg Ask for price

G418 Powder, 1 g
BS.A291-21 1 g Ask for price
Description: G418-BCPowder 1 g

G418 Powder, 5 g
BS.A291-23 5 g Ask for price
Description: G418-BScrystalline powder 5 gnon-sterile G 418 sulphate

G418 Powder, 10 g
BS.A291-25 10 g Ask for price
Description: G418-BCPowder 10 g

Sephadex G-10 100g - EACH
17001001 EACH
EUR 390.15

Sephadex G-10 500g - EACH
17001002 EACH
EUR 1721.25

Sephadex G-15 100g - EACH
17002001 EACH
EUR 400.95

Sephadex G-75 100g - EACH
17005001 EACH
EUR 573.75

G-418 SULFATE - 1g
PM-A4215/1 1g
EUR 37.9

G-292 clone A141B1
ABC-TC0264 1 vial Ask for price
Description: Organism: Homo sapiens, human; Tissue: bone; Disease: osteosarcoma.

G-418. Sulfate Solid
CR007-001 1 g
EUR 62

G-418. Sulfate Solid
CR007-005 5g
EUR 220

Brilliant blue G-250
MBS5772656-100mg 100mg
EUR 170

Brilliant blue G-250
MBS5772656-200mg 200mg
EUR 200

Brilliant blue G-250
MBS5772656-500mg 500mg
EUR 290

Brilliant blue G-250
MBS5772656-50mg 50mg
EUR 150

Brilliant blue G-250
MBS5772656-5mg 5mg
EUR 145

Brilliant blue G-250
T20731-10mg 10mg Ask for price
Description: Brilliant blue G-250

Brilliant blue G-250
T20731-1g 1g Ask for price
Description: Brilliant blue G-250

Brilliant blue G-250
T20731-1mg 1mg Ask for price
Description: Brilliant blue G-250

Brilliant blue G-250
T20731-50mg 50mg Ask for price
Description: Brilliant blue G-250

Brilliant blue G-250
T20731-5mg 5mg Ask for price
Description: Brilliant blue G-250

Brilliant Blue G-250
1021075 25 25 g Ask for price

Brilliant Blue G-250
1021075 5 5 g Ask for price

G-749 (FLT3 inhibitor)
SC1054-10mM 10 mM x 0.2 mL Ask for price

G-749 (FLT3 inhibitor)
SC1054-25mg 25 mg Ask for price

G-749 (FLT3 inhibitor)
SC1054-5mg 5 mg Ask for price

Geneticin, G-418 Sulfate
A2513-1000 1 g
EUR 49.6
Description: Microbiology & Virology|Antibiotic

Geneticin, G-418 Sulfate
A2513-5000 5 g
EUR 168
Description: Microbiology & Virology|Antibiotic

Sephadex G-100 Superfine
Se-482C 100 g
EUR 1808
Description: Chromatography Reagents

10G Coomassie Blue G-250 - 10G
NAT1362 10G
EUR 195.75

HBsAg adw Mutant G-145-R Recombinant (HBsAg adw Mutant G-145-R)
PT_40823
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 µg
  • 50 µg
  • 1 mg

HBsAg ayw Mutant G-145-R Recombinant (HBsAg ayw Mutant G-145-R)
PT_40835
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 µg
  • 50 µg
  • 1 mg

Sephadex G-100 Superfine 100g - EACH
17006101 EACH
EUR 1005.75

50mg/mL G-418 Solution
MBS2567645-10mL 10mL
EUR 125

50mg/mL G-418 Solution
MBS2567645-5x10mL 5x10mL
EUR 545

50mg/mL G-418 Solution
PB180125 10mL
EUR 55
Description: Antibiotics

50mg/mL G-418 Solution
PB180125-10mL 10 mL
EUR 55
Description: Supplements & Reagents

50 G G418 SULFATE, POWDER
61-234-RK 50 g/pk
EUR 1610.4
Description: Media Catalog; Cell Culture Reagents

Coomassie Blue G-250 2X
40340000-1 500 mL
EUR 46.15

Coomassie Blue G-250 2X
40340000-2 1 L
EUR 83.81

SEPHADEX G-25 FINE, 100 G - EACH
GE17-0032-01 EACH
EUR 434.7

Anti-G gamma14 (1G11-C7)
YF-MA13281 100 ug
EUR 435.6
Description: Mouse monoclonal to G gamma14

Gel filtration medium G-100
MBS5801178-5mg 5(mg
EUR 915

Gel filtration medium G-100
MBS5801178-5x5mg 5x5(mg
EUR 3970

Gel filtration medium G-100
T41039-10mg 10mg Ask for price
Description: Gel filtration medium G-100

Gel filtration medium G-100
T41039-1g 1g Ask for price
Description: Gel filtration medium G-100

Gel filtration medium G-100
T41039-1mg 1mg Ask for price
Description: Gel filtration medium G-100

Gel filtration medium G-100
T41039-50mg 50mg Ask for price
Description: Gel filtration medium G-100

Gel filtration medium G-100
T41039-5mg 5mg Ask for price
Description: Gel filtration medium G-100

Compact balance, 0,01g x 2000 g
CB-2002N each
EUR 190

Coomasie Brilliant Blue G-250
A2329-25G 25G
EUR 38.5
Description: Ultra Pure

Coomasie Brilliant Blue G-250
A2329-5G 5G
EUR 12.1
Description: Ultra Pure

Express Coomassie Stain G-250
40340020-1 1 L
EUR 122.35

Express Coomassie Stain G-250
40340020-2 500 mL
EUR 83.47

G-418 (Geneticin) Solution - 100ml
LM-A4115/100 100ml
EUR 134.31

G-418 (Geneticin) Solution - 20ml
LM-A4115/20 20ml
EUR 30.25

Anti-HRSV-A/B G/Major surface glycoprotein G Antibody (131-2G)
MBS1568531-01mg 0.1mg
EUR 405

Anti-HRSV-A/B G/Major surface glycoprotein G Antibody (131-2G)
MBS1568531-5x01mg 5x0.1mg
EUR 1520

Sephadex G-25 Fine 100g - EACH
17003201 EACH
EUR 448.2

Mc modules directly bind actin filaments and mediate activity-dependent stabilisation of F-actin in dendritic spines, a key event of synaptic plasticity. In vitro, Mc modules enhance actin filament nucleation and promote the formation of stable, highly ordered filament bundles. Activity-induced phosphorylation of MAP6 likely controls its transfer to the spine cytoskeleton.