Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation.

During Drosophila and vertebrate brain development, the conserved transcription factor Prospero/Prox1 is an important regulator of the transition between proliferation and differentiation. Prospero level is low in neural stem cells and their immediate progeny, but is upregulated in larval neurons and it is unknown how this process is controlled.

ACPT-I
B5051-10	ApexBio	10 mg	EUR 318

ACPT-I
B5051-25	ApexBio	25 mg	EUR 659

ACPT-I
B5051-5	ApexBio	5 mg	EUR 196

ACPT Antibody
1-CSB-PA253255	Cusabio	EUR 317.00 EUR 244.00	100ul 50ul
Form: Liquid Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against ACPT. Recognizes ACPT from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

ACPT antibody
70R-7296	Fitzgerald	50 ug	EUR 467
Description: Rabbit polyclonal ACPT antibody raised against the middle region of ACPT

ACPT-II
B6601-10	ApexBio	10 mg	EUR 293

ACPT-II
B6601-5	ApexBio	5 mg	EUR 196

ACPT-II
B6601-50	ApexBio	50 mg	EUR 1024

ACPT siRNA
20-abx906568	Abbexa	EUR 551.00 EUR 732.00	15 nmol 30 nmol
Shipped within 5-10 working days.

anti-ACPT
YF-PA21789	Abfrontier	50 ul	EUR 363
Description: Mouse polyclonal to ACPT

ACPT Blocking Peptide
33R-9175	Fitzgerald	100 ug	EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACPT antibody, catalog no. 70R-7296

ACPT Conjugated Antibody
C37143	SAB	100ul	EUR 397

anti- ACPT antibody
FNab00103	FN Test	100µg	EUR 548.75
Recommended dilution: WB: 1:500-1:5000 Immunogen: acid phosphatase, testicular Uniprot ID: Q9BZG2 Gene ID: 93650 Research Area: Metabolism
Description: Antibody raised against ACPT

Anti-ACPT antibody
PAab00103	Lifescience Market	100 ug	EUR 386

ACPT ELISA KIT|Human
EF007580	Lifescience Market	96 Tests	EUR 689

Human ACPT shRNA Plasmid
20-abx964222	Abbexa	EUR 801.00 EUR 1121.00	150 µg 300 µg
Shipped within 15-20 working days.

ACPT Recombinant Protein (Human)
RP045694	ABM	100 ug	Ask for price

ACPT Recombinant Protein (Mouse)
RP113918	ABM	100 ug	Ask for price

ACPT Recombinant Protein (Rat)
RP188942	ABM	100 ug	Ask for price

Acid Phosphatase, Testicular (ACPT) Antibody
abx037579-100ug	Abbexa	100 ug	EUR 391
Shipped within 5-10 working days.

Acid Phosphatase, Testicular (ACPT) Antibody
abx230103-100ug	Abbexa	100 ug	EUR 509
Shipped within 5-12 working days.

Acpt ORF Vector (Rat) (pORF)
ORF062982	ABM	1.0 ug DNA	EUR 506

ACPT ORF Vector (Human) (pORF)
ORF015232	ABM	1.0 ug DNA	Ask for price

Acpt ORF Vector (Mouse) (pORF)
ORF037974	ABM	1.0 ug DNA	EUR 506

Acpt sgRNA CRISPR Lentivector set (Rat)
K6218901	ABM	3 x 1.0 ug	EUR 339

Acpt sgRNA CRISPR Lentivector set (Mouse)
K3032801	ABM	3 x 1.0 ug	EUR 339

ACPT sgRNA CRISPR Lentivector set (Human)
K0031801	ABM	3 x 1.0 ug	EUR 339

Human Testicular acid phosphatase, ACPT ELISA KIT
ELI-19713h	Lifescience Market	96 Tests	EUR 824

Human Acid Phosphatase, Testicular (ACPT) ELISA Kit
abx385591-96tests	Abbexa	96 tests	EUR 911
Shipped within 5-12 working days.

Acpt sgRNA CRISPR Lentivector (Rat) (Target 1)
K6218902	ABM	1.0 ug DNA	EUR 154

Acpt sgRNA CRISPR Lentivector (Rat) (Target 2)
K6218903	ABM	1.0 ug DNA	EUR 154

Acpt sgRNA CRISPR Lentivector (Rat) (Target 3)
K6218904	ABM	1.0 ug DNA	EUR 154

Acpt sgRNA CRISPR Lentivector (Mouse) (Target 1)
K3032802	ABM	1.0 ug DNA	EUR 154

Acpt sgRNA CRISPR Lentivector (Mouse) (Target 2)
K3032803	ABM	1.0 ug DNA	EUR 154

Acpt sgRNA CRISPR Lentivector (Mouse) (Target 3)
K3032804	ABM	1.0 ug DNA	EUR 154

ACPT sgRNA CRISPR Lentivector (Human) (Target 1)
K0031802	ABM	1.0 ug DNA	EUR 154

ACPT sgRNA CRISPR Lentivector (Human) (Target 2)
K0031803	ABM	1.0 ug DNA	EUR 154

ACPT sgRNA CRISPR Lentivector (Human) (Target 3)
K0031804	ABM	1.0 ug DNA	EUR 154

ACPT Protein Vector (Mouse) (pPB-C-His)
PV151894	ABM	500 ng	EUR 603

ACPT Protein Vector (Mouse) (pPB-N-His)
PV151895	ABM	500 ng	EUR 603

ACPT Protein Vector (Mouse) (pPM-C-HA)
PV151896	ABM	500 ng	EUR 603

ACPT Protein Vector (Mouse) (pPM-C-His)
PV151897	ABM	500 ng	EUR 603

ACPT Protein Vector (Rat) (pPB-C-His)
PV251926	ABM	500 ng	EUR 603

ACPT Protein Vector (Rat) (pPB-N-His)
PV251927	ABM	500 ng	EUR 603

ACPT Protein Vector (Rat) (pPM-C-HA)
PV251928	ABM	500 ng	EUR 603

ACPT Protein Vector (Rat) (pPM-C-His)
PV251929	ABM	500 ng	EUR 603

ACPT Protein Vector (Human) (pPB-His-MBP)
PV319302	ABM	500 ng	Ask for price

ACPT Protein Vector (Human) (pPB-His-GST)
PV319303	ABM	500 ng	Ask for price

ACPT Protein Vector (Human) (pPB-C-His)
PV060925	ABM	500 ng	Ask for price

ACPT Protein Vector (Human) (pPB-N-His)
PV060926	ABM	500 ng	Ask for price

ACPT Protein Vector (Human) (pPM-C-HA)
PV060927	ABM	500 ng	Ask for price

ACPT Protein Vector (Human) (pPM-C-His)
PV060928	ABM	500 ng	Ask for price

Acpt 3'UTR Luciferase Stable Cell Line
TU101290	ABM	1.0 ml	Ask for price

Acpt 3'UTR GFP Stable Cell Line
TU151290	ABM	1.0 ml	Ask for price

Acpt 3'UTR Luciferase Stable Cell Line
TU200186	ABM	1.0 ml	Ask for price

Acpt 3'UTR GFP Stable Cell Line
TU250186	ABM	1.0 ml	Ask for price

ACPT 3'UTR GFP Stable Cell Line
TU050190	ABM	1.0 ml	EUR 1394

ACPT 3'UTR Luciferase Stable Cell Line
TU000190	ABM	1.0 ml	EUR 1394

Recombinant Salmonella acpT Protein (aa 1-192)
VAng-Wyb0921-1mgEcoli	Creative Biolabs	1 mg (E. coli)	EUR 3630
Description: Salmonella typhi 4'-phosphopantetheinyl transferase AcpT, recombinant protein.

Recombinant Salmonella acpT Protein (aa 1-192)
VAng-Wyb0921-500gEcoli	Creative Biolabs	500 µg (E. coli)	EUR 2460
Description: Salmonella typhi 4'-phosphopantetheinyl transferase AcpT, recombinant protein.

Recombinant Salmonella acpT Protein (aa 1-192)
VAng-Wyb0921-50gEcoli	Creative Biolabs	50 µg (E. coli)	EUR 1676
Description: Salmonella typhi 4'-phosphopantetheinyl transferase AcpT, recombinant protein.

ACPT Protein Vector (Human) (pPM-N-D-C-HA)
PV319304	ABM	500 ng	Ask for price

ACPT Protein Vector (Human) (pPM-N-D-C-His)
PV319305	ABM	500 ng	Ask for price

Acpt sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
K6218905	ABM	3 x 1.0 ug	EUR 376

Acpt sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
K3032805	ABM	3 x 1.0 ug	EUR 376

ACPT sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
K0031805	ABM	3 x 1.0 ug	EUR 376

Acpt sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)
K6218906	ABM	1.0 ug DNA	EUR 167

Acpt sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)
K6218907	ABM	1.0 ug DNA	EUR 167

Acpt sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)
K6218908	ABM	1.0 ug DNA	EUR 167

Acpt sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)
K3032806	ABM	1.0 ug DNA	EUR 167

Acpt sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
K3032807	ABM	1.0 ug DNA	EUR 167

Acpt sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
K3032808	ABM	1.0 ug DNA	EUR 167

ACPT sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
K0031806	ABM	1.0 ug DNA	EUR 167

ACPT sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
K0031807	ABM	1.0 ug DNA	EUR 167

ACPT sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)
K0031808	ABM	1.0 ug DNA	EUR 167

Here, we use single molecule fluorescent in situ hybridisation to show that larval neurons selectively transcribe a long prospero mRNA isoform containing a 15 kb 3′ untranslated region, which is bound in the brain by the conserved RNA-binding protein Syncrip/hnRNPQ.

Syncrip binding increases the mRNA stability of the long prospero isoform, which allows an upregulation of Prospero protein production. Adult flies selectively lacking the long prospero isoform show abnormal behaviour that could result from impaired locomotor or neurological activity.