Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation.

During Drosophila and vertebrate brain development, the conserved transcription factor Prospero/Prox1 is an important regulator of the transition between proliferation and differentiation. Prospero level is low in neural stem cells and their immediate progeny, but is upregulated in larval neurons and it is unknown how this process is controlled.

ACPT antibody
70R-7296 50 ug
EUR 467.00
Description: Rabbit polyclonal ACPT antibody raised against the middle region of ACPT

ACPT Antibody
1-CSB-PA829218
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against ACPT. Recognizes ACPT from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

ACPT-II
B6601-10 10 mg
EUR 293.00

ACPT-II
B6601-5 5 mg
EUR 196.00

ACPT-II
B6601-50 50 mg
EUR 1024.00

ACPT-I
B5051-10 10 mg
EUR 318.00

ACPT-I
B5051-25 25 mg
EUR 659.00

ACPT-I
B5051-5 5 mg
EUR 196.00

ACPT Antibody
1-CSB-PA253255
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against ACPT. Recognizes ACPT from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

anti-ACPT
YF-PA21789 50 ul
EUR 363.00
Description: Mouse polyclonal to ACPT

ACPT Blocking Peptide
33R-9175 100 ug
EUR 180.00
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACPT antibody, catalog no. 70R-7296

ACPT Conjugated Antibody
C37143 100ul
EUR 397.00

Anti-ACPT antibody
PAab00103 100 ug
EUR 386.00

anti- ACPT antibody
FNab00103 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:5000
  • Immunogen: acid phosphatase, testicular
  • Uniprot ID: Q9BZG2
  • Gene ID: 93650
  • Research Area: Metabolism
Description: Antibody raised against ACPT

ACPT ELISA KIT|Human
EF007580 96 Tests
EUR 689.00

Human ACPT shRNA Plasmid
20-abx964222
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg
  • Shipped within 15-20 working days.

ACPT Recombinant Protein (Human)
RP045694 100 ug Ask for price

ACPT Recombinant Protein (Mouse)
RP113918 100 ug Ask for price

ACPT Recombinant Protein (Rat)
RP188942 100 ug Ask for price

Acid Phosphatase, Testicular (ACPT) Antibody
abx230103-100ug 100 ug
EUR 509.00
  • Shipped within 5-12 working days.

Acid Phosphatase, Testicular (ACPT) Antibody
abx037579-100ug 100 ug
EUR 391.00
  • Shipped within 5-10 working days.

Acpt ORF Vector (Rat) (pORF)
ORF062982 1.0 ug DNA
EUR 506.00

ACPT ORF Vector (Human) (pORF)
ORF015232 1.0 ug DNA Ask for price

Acpt ORF Vector (Mouse) (pORF)
ORF037974 1.0 ug DNA
EUR 506.00

Acpt sgRNA CRISPR Lentivector set (Mouse)
K3032801 3 x 1.0 ug
EUR 339.00

ACPT sgRNA CRISPR Lentivector set (Human)
K0031801 3 x 1.0 ug
EUR 339.00

Acpt sgRNA CRISPR Lentivector set (Rat)
K6218901 3 x 1.0 ug
EUR 339.00

Human Testicular acid phosphatase, ACPT ELISA KIT
ELI-19713h 96 Tests
EUR 824.00

Human Acid Phosphatase, Testicular (ACPT) ELISA Kit
abx385591-96tests 96 tests
EUR 911.00
  • Shipped within 5-12 working days.

Acpt sgRNA CRISPR Lentivector (Mouse) (Target 1)
K3032802 1.0 ug DNA
EUR 154.00

Acpt sgRNA CRISPR Lentivector (Mouse) (Target 2)
K3032803 1.0 ug DNA
EUR 154.00

Acpt sgRNA CRISPR Lentivector (Mouse) (Target 3)
K3032804 1.0 ug DNA
EUR 154.00

ACPT sgRNA CRISPR Lentivector (Human) (Target 1)
K0031802 1.0 ug DNA
EUR 154.00

ACPT sgRNA CRISPR Lentivector (Human) (Target 2)
K0031803 1.0 ug DNA
EUR 154.00

ACPT sgRNA CRISPR Lentivector (Human) (Target 3)
K0031804 1.0 ug DNA
EUR 154.00

ACPT Protein Vector (Human) (pPB-His-MBP)
PV319302 500 ng Ask for price

ACPT Protein Vector (Human) (pPB-His-GST)
PV319303 500 ng Ask for price

ACPT Protein Vector (Mouse) (pPB-C-His)
PV151894 500 ng
EUR 603.00

ACPT Protein Vector (Mouse) (pPB-N-His)
PV151895 500 ng
EUR 603.00

ACPT Protein Vector (Mouse) (pPM-C-HA)
PV151896 500 ng
EUR 603.00

ACPT Protein Vector (Mouse) (pPM-C-His)
PV151897 500 ng
EUR 603.00

ACPT Protein Vector (Rat) (pPB-C-His)
PV251926 500 ng
EUR 603.00

ACPT Protein Vector (Rat) (pPB-N-His)
PV251927 500 ng
EUR 603.00

ACPT Protein Vector (Rat) (pPM-C-HA)
PV251928 500 ng
EUR 603.00

ACPT Protein Vector (Rat) (pPM-C-His)
PV251929 500 ng
EUR 603.00

ACPT 3'UTR Luciferase Stable Cell Line
TU000190 1.0 ml
EUR 1394.00

ACPT 3'UTR GFP Stable Cell Line
TU050190 1.0 ml
EUR 1394.00

Acpt sgRNA CRISPR Lentivector (Rat) (Target 1)
K6218902 1.0 ug DNA
EUR 154.00

Acpt sgRNA CRISPR Lentivector (Rat) (Target 2)
K6218903 1.0 ug DNA
EUR 154.00

Acpt sgRNA CRISPR Lentivector (Rat) (Target 3)
K6218904 1.0 ug DNA
EUR 154.00

ACPT Protein Vector (Human) (pPB-C-His)
PV060925 500 ng Ask for price

ACPT Protein Vector (Human) (pPB-N-His)
PV060926 500 ng Ask for price

ACPT Protein Vector (Human) (pPM-C-HA)
PV060927 500 ng Ask for price

ACPT Protein Vector (Human) (pPM-C-His)
PV060928 500 ng Ask for price

Acpt 3'UTR Luciferase Stable Cell Line
TU200186 1.0 ml Ask for price

Acpt 3'UTR GFP Stable Cell Line
TU250186 1.0 ml Ask for price

Acpt 3'UTR Luciferase Stable Cell Line
TU101290 1.0 ml Ask for price

Acpt 3'UTR GFP Stable Cell Line
TU151290 1.0 ml Ask for price

Recombinant Salmonella acpT Protein (aa 1-192)
VAng-Wyb0921-1mgEcoli 1 mg (E. coli)
EUR 3630.00
Description: Salmonella typhi 4'-phosphopantetheinyl transferase AcpT, recombinant protein.

Recombinant Salmonella acpT Protein (aa 1-192)
VAng-Wyb0921-500gEcoli 500 µg (E. coli)
EUR 2460.00
Description: Salmonella typhi 4'-phosphopantetheinyl transferase AcpT, recombinant protein.

Recombinant Salmonella acpT Protein (aa 1-192)
VAng-Wyb0921-50gEcoli 50 µg (E. coli)
EUR 1676.00
Description: Salmonella typhi 4'-phosphopantetheinyl transferase AcpT, recombinant protein.

ACPT Protein Vector (Human) (pPM-N-D-C-HA)
PV319304 500 ng Ask for price

ACPT Protein Vector (Human) (pPM-N-D-C-His)
PV319305 500 ng Ask for price

Acpt sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
K3032805 3 x 1.0 ug
EUR 376.00

ACPT sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
K0031805 3 x 1.0 ug
EUR 376.00

Acpt sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
K6218905 3 x 1.0 ug
EUR 376.00

Acpt sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)
K3032806 1.0 ug DNA
EUR 167.00

Acpt sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
K3032807 1.0 ug DNA
EUR 167.00

Acpt sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
K3032808 1.0 ug DNA
EUR 167.00

ACPT sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
K0031806 1.0 ug DNA
EUR 167.00

ACPT sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
K0031807 1.0 ug DNA
EUR 167.00

ACPT sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)
K0031808 1.0 ug DNA
EUR 167.00

Acpt sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)
K6218906 1.0 ug DNA
EUR 167.00

Acpt sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)
K6218907 1.0 ug DNA
EUR 167.00

Acpt sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)
K6218908 1.0 ug DNA
EUR 167.00

Here, we use single molecule fluorescent in situ hybridisation to show that larval neurons selectively transcribe a long prospero mRNA isoform containing a 15 kb 3′ untranslated region, which is bound in the brain by the conserved RNA-binding protein Syncrip/hnRNPQ.

Syncrip binding increases the mRNA stability of the long prospero isoform, which allows an upregulation of Prospero protein production. Adult flies selectively lacking the long prospero isoform show abnormal behaviour that could result from impaired locomotor or neurological activity.